研究業績

令和７年度

  • Shinnosuke Yasugaki (Co-first author), Ami Kaneko (Co-first author), Hibiki Okamura, Hideki Hayakawa, Kensuke Ikenaka, Cesar Aguirre, Masashi Yanagisawa, Hideki Mochizuki, Kousuke Baba, Yu Hayashi. A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction. Neuroscience Research. 2026, 224, 105023, doi:10.1016/j.neures.2026.105023.
  • Naoko Hayashi, Asako Kawai, Yu Hayashi. Social rank and social environment combinedly affect REM sleep in mice. Scientific Reports. 2026, 16(1), 871, doi:10.1038/s41598-025-32402-2.
  • Naoko Hayashi, Yuto Okabe, Kaeko Tanaka, Mina Kitajima, KeisukeTaniguchi, Motoko Yanagita, Yu Hayashi. Dynamic changes in sleep architecture in a mouse model of acute kidney injury transitioning to chronic kidney disease. Frontiers in Neuroscience. 2025, 19, 1581494, doi:10.3389/fnins.2025.1581494.
  • Shinichi Miyazaki, Yu Hayashi. Circular RNA as a potential biomarker for obstructive sleep apnea. Sleep and Biological Rhythms. 2025, 23, 257, doi:10.1007/s41105-025-00585-w.
  • Hane M, Naramura A, Hayakawa K, Abe C, Nakagawa T, Kushima I, Furukawa S, Fukami Y, Ikegami K, Saigoh K, Kusunoki S, Katsuno M, Ozaki N, Kitajima K, Sato C. A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders. Sci Rep. 2025, 15, 19033, doi:10.1038/s41598-025-02583-x.
  • Naito K, Iwamoto K, Miyata S, Okada I, Kawai K, Fujimoto A, Kogo Y, Mori D, Matsuyama N, Ando M, Ozaki N, Ikeda M. Effect of lemborexant on sleep-wake state discrepancy in participants with insomnia disorder. Psychopharmacology (Berl). 2026, 243, 133-143, doi:10.1007/s00213-025-06845-4.
  • Miyata S, Iwamoto K, Ito M, Okada I, Matsuyama N, Fujimoto A, Kogo Y, Nishiwaki H, Ueyama J, Ohno K, Ozaki N. Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant. Nat Sci Sleep. 2025, 17, 1709-1726, doi:10.2147/NSS.S526037.
  • Zhu W, Sobue A, Tanaka R, Hada K, Ibi D, Liu Y, Matsuzaki T, Nagai T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Ikesue H, Yamada K. Acute systemic immune challenge induces cognitive impairments and anhedonia through interferon-induced transmembrane protein 3 in adult male mice. Behav Brain Res. 2025, 115832, doi:10.1016/j.bbr.2025.115832.
  • Dong G, Mori D, Matsuzaki T, Tanaka R, Itoh N, Matsui T, Sato A, Arioka Y, Okumura H, Fukaya R, Kuba H, Nagai T, Nabeshima T, Ikesue H, Kohno T, Hattori M, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development. Pharmacol Res. 2025, 221, 107986, doi:10.1016/j.phrs.2025.107986.
  • Zhu Y, Kitagawa K, Mori D, Matsuzaki T, Nagai T, Nabeshima T, Takemoto-Kimura S, Ikesue H, Ozaki N, Mizoguchi H, Yamada K. Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion. Eur J Pharmacol. 2025, 178407, doi:10.1016/j.ejphar.2025.178407.
  • Miyata S, Kawai K, Iwamoto K, Fujishiro H, Ozaki N, Ikeda M. Impact of irregular sleep patterns on mental health and sleep quality assessed by home-based EEG monitoring. Chronobiol Int. 2026, 43, 500-510, doi:10.1080/07420528.2025.2606288.
  • Mizutani R, Saiga R, Yamamoto Y, Inomoto C, Kajiwara H, Kakimoto Y, Yasutake M, Uesugi M, Takeuchi A, Uesugi K, Terada Y, Suzuki Y, Nikitin V, De Carlo F, Torii Y, Kushima I, Ozaki N, Iritani S, Arai M, Oshima KI, Itokawa M. Structural alteration of neurons in schizophrenia and its relation with auditory hallucination. Eur Psychiatry. 2026, 1-20, doi:10.1192/j.eurpsy.2026.10163.
  • Miyata S, Iwamoto K, Kawai K, Fujishiro H, Nakagome K, Ozaki N, Ikeda M. Telemonitored sleep quality and daily activity are associated with mental health outcomes among Japanese workers. Sci Rep. 2026, 16, doi:10.1038/s41598-026-38584-7. 
  • Kawai K, Iwamoto K, Miyata S, Fujishiro H, Ikeda M, Ozaki N. Daily associations of subjective and objective sleep parameters with restorative sleep and morning sleepiness in Japanese working adults. Sci Rep. 2026, 16, doi:10.1038/s41598-026-43784-2.
  • Tanaka R, Liao J, Liu Y, Zhu W, Fukuzawa K, Kondo M, Sawahata M, Mori D, Mouri A, Kubota H, Tachibana D, Kobayashi Y, Matsuzaki T, Nagai T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia. Mol Psychiatry. in press, doi:10.1038/s41380-026-03567-7.
  • Ueda J, Uemura N, Chang J, Hirato T, Ishimoto T, Oono M, Matsuzawa S, Matsumoto R, Yamakado H, Takahashi R “Perampanel Blocks Transsynaptic α-Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease” Mov Disord. doi: 10.1002/mds.70191. Online ahead of print. 2026
  • Uemura N “Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications” Neurosci Res. 216:104905, 2025
  • Kanatsu-Shinohara M, Shiromoto Y, Ogonuki N, Inoue K, Mochida K, Kabashima K, Kong Y, Toyokuni S, Yamamoto T, Ogura A, Shinohara T. Mouse ICSI impairs infertility of male offspring by disruption of fetomaternal tolerance. Development  In press.

令和６年度

  • Wang Z, Okamura H, Luo S, Hayashi Y, and Takizaw. Extraction of c-Fos Protein Regions from Mouse Brain Slice Images using Multi-channelization, 1×1 Convolution and U-Net.  HSCIS&ISIS DOI: 10.1109/SCISISIS61014.2024.10760049.
  • 林 悠. 睡眠のひみつ 知るほどおもしろい「眠り」のちしき.メイツ出版.
  • 千葉 隆之介, 林 直子, 林 悠. マウスにおける REM・NREM 睡眠制御と線虫の睡眠から見る新たな睡眠制御メカニズム. 克誠堂出版. 2025.74.1.10-18.https://doi.org/10.18916/masui.2025010006
  • 皆川 栄子. Alzheimer病と睡眠. 脳神経内科. 2025, 102(1), 30-35.
  • 柏木 光昭，林 悠. レム睡眠に重要な脳幹神経回路の発見と，パーキンソン病に伴う睡眠異常の原因解明. 実験医学. 2025.43.3.426-429
  • 林 悠. ぐっすり眠り、スッキリ目覚める! 明日が変わる. 睡眠の科学大全.ナツメ社.
  • Kawai K, Iwamoto K, Miyata S, Okada I, Ando M, Fujishiro H, Noda A, Ozaki N, Ikeda M. Association of sleep-wake state discrepancy and depressive symptoms with restorative sleep in patients with depression. Sleep Med. 2025, 127. 166-169. doi:10.1016/j.sleep.2025.01.021.
  • Murakami Y, Obuchi M, Kamizawa H, Miyazaki S, Kishimura A, Oketani R, Hiramatsu K, Leproux P, Hayashi Y, Shiraki K, & Kano, H . Exploring liquid–liquid phase separation in vitro and in vivo using multimodal nonlinear optical imaging. Analytical Sciences DOI: 10.1007/s44211-025-00747-3. 
  • Yoshifumi Arai, Mitsuaki Kashiwagi, Takeshi Kanda, Iyo Koyanagi, Masanori Sakaguchi, Masashi Yanagisawa, Yoshimasa Koyama, Yu Hayashi.
    Diverse firing profiles of Crhbp-positive neurons in the dorsal pons suggestive of their pleiotropic roles in REM sleep regulation in mice. Journal of Neuroscience: in press